In standard dosages, mg supplements contain 4. However, the lithium orotate dose can vary between supplements, which could affect lithium orotate health benefits. Lithium is vital for early fetal development , but lithium supplements are not recommended in pregnant women. Lithium is a go-to option for bipolar disorder because it has neuroprotective properties associated with the expression of BDNF brain-derived neurotrophic factor associated with neuron growth.
Although the exact mechanisms are not known, lithium helps stabilize and improve mood , which is why it is a part of treatment for anxiety, depression, bipolar disorder, and more. As we mentioned, 4. However, the lithium orotate dosage recommended by doctors may vary.
The evidence suggests an intake of at least 1 mg of lithium per day , and most supplements fit in the mg range. However some go as high as 20 mg, as explained in our lithium orotate reviews.
Be aware of dosages when checking the labels, as manufacturers are not always transparent about them. Sometimes it may not be clear whether they state the salt quantities or the lithium weight. Lithium is not metabolized, and is eliminated through the kidneys within 48 hours.
The expected lithium orotate half-life is around 24 hours. Lithium carbonate is a standard form of lithium prescribed for bipolar disorder.
It contains Once the lithium salts enter your body, they dissolve, and lithium ions affect several pathways in your body. Because lithium carbonate has a much higher dosage of this alkali metal, you can expect faster absorption, quicker effects, and higher potency than with lithium orotate supplements. Some lithium orotate research found higher concentrations of lithium in the brain of rats that were given lithium orotate vs.
These findings hint at the possible ability of lithium orotate to cross the blood-brain barrier more efficiently. However, later lithium orotate studies suggested that the experiments used high doses, which might have affected the renal function and clearance, explaining the higher lithium concentrations in the brain.
Lithium Aspartate is another OTC supplement, similar to lithium orotate. Since lithium has long been used for bipolar disorder, it is only natural that people are trying these OTC supplements to improve mood, decrease brain aging, and improve cognitive performance. However, studies examining lithium aspartate are scarce.
If you decide to get this supplement, you should check the label and determine how much lithium it has. As a psychiatrist, I generally recommend Lithium for clients with behavioral health issues such as bipolar disorder and treatment-resistant depression with suicidal thinking. When treating these illnesses, dosages of Lithium can reach mg daily. Supplements contain much smaller quantities of Lithium than the prescription form and generally range from 1mg to 5mg per dosage.
Helo David. Ive recently been takin L. O but had my fears that the combination of Lithium and Concerta Adhd med. And my kidneys are fine. As long as you follow the dosage recommendations and do not have kidney problems you should not have a problem. But if it worries you then get your labs done a couple of times per year. Salem, it is certainly safe as long as it works for you and your system. You should have noticed a problem by now if you were going to.
Hi David. Lilthium is amazing. I now take a stack and lilthium included but I am on a tiny sub clinical dose but worried about interactions. Hello David! I frequently need to urinate. Is it safe for me to continue taking lithium ortate? I take two 5mg capsules in a day. Malik, you should not be experiencing those symptoms from using Lithium Orotate.
Try only one dose per day and see if that helps. Or only use Lithium Orotate as needed. You should not experience any side effects with 20 mg Lithium Orotate. There is the very, very rare possibility of experiencing nausea, vomiting, or diarrhea. But those symptoms usually associated wtih high dose Lithium like they prescribe for psychosis and mania. I took the basic 5mg caps two nights in a row. I felt something for a bout an hour afterwards, just a little tiny heady feeling.
Today I felt sort of lightheaded and a bit disoriented. I also take Turmeric, Ashwaganda, Magnesium glycinate, omegas, vitamin D, Maca in the morning, thyroid meds, Claritin, Chinese herbs, and desiccated liver supplement. Denise, did you see this part of my Side Effects section above? If none of that applies to you and you experienced what you did the 2nd day of using Lithium Orotate it could be the wrong supplement for you. Because if it is two then cut your dose back to one tablet and see if that helps.
If not then cut the tablet in half and see if that helps. Thank you for your reply. Also, saw my acupuncturist and she thinks I have a cold, due to some sinus congestion, and so that may have been what was making me feel off kilter. So, maybe it was just bad timing. I had only tried one 5 mg cap at night. I think that I felt better mentally for the first two days, and then started feeling off after that. I stopped taking it and still felt off for the next several days.
I think I will try to order some 1 mg caps and try those when this congestion is gone. I tend to need lower doses of everything than most people. Really appreciate your site. I took an L glutamine supplement that feels as though it has flooded my brain with glutamate.
Would the dose recommended above for a week help me clear it out? Carolyn, Lithium Orotate helps prevent glutamate toxicity it may help you. Try a standard dose of 5 mg which is usually a mg tablet or capsule 3-times per day. Hello — my Dr. I remember I tried taking the brand of Lithium orotate you recommend at mg a day and noticed a difference, but thought I was kidding myself. I think I might quit Wellbutrin and go back to L. O… is mg 1 x a day that most?
Do you recommend trying them together? Steph, Wellbutrin and Lithium Orotate are very different in the way they work in your brain. Lithium Orotate is micro-dosing lithium which is bound to orotic acid which helps lithium better access the brain.
Each dose is only 5 mg of lithium. You can safely use that dose 3-times per day. Your email address will not be published. However, early research shows some promise. Basic biology suggests that many enzymes, hormones, vitamins, and growth factors require lithium to work. Lithium also appears to support the immune and nervous systems. Additionally, some scientists are currently investigating whether it promotes the regeneration of cells. Some suspect that it might even protect telomeres and prolong lifespan — but this hypothesis remains unproven [ 2 ].
Currently, lithium orotate is poorly-researched, and its overall safety in human users has not been determined. Additionally, lithium orotate supplements have not been officially approved by the FDA for any medical use or other health application. Supplements generally lack solid clinical research.
Always make sure to speak with your doctor before supplementing with any new compounds. Some early low-quality studies on lithium orotate suggested that this form of lithium may be better at penetrating the blood-brain barrier , theoretically allowing it to reach higher levels in the brain. However, this has not yet been directly proven in any clinical trials [ 3 , 4 ]. Additionally, many studies have challenged these claims about lithium orotate. For now, its use is not backed up by science [ 5 , 6 ].
Some supplements contain lithium citrate or aspartate salts. The most important distinction between lithium orotate and lithium carbonate the prescription form of lithium is their dosage.
In contrast, prescription formulations of lithium carbonate typically contain about 19 mg of elemental lithium per mg [ 7 ]. This means that prescription lithium drugs are over 30 times stronger than lithium orotate.
Since supplements contain much lower amounts of lithium, they are less likely to cause the same side-effects and toxicity of prescription lithium. On the other hand, the safety of orotic acid salts — including lithium orotate — has not been firmly established. Lithium carbonate has been around for decades and its use is supported by many clinical studies [ 8 ]. Limited studies suggest that these trace amounts of lithium may offer some health benefits.
However, the available studies tend to be small-scale, low-quality trials, and lithium dosages vary considerably across different studies. This makes their findings unreliable and difficult to interpret [ 2 ].
Research suggests that the average person requires about 1 mg of lithium per day. Prescription doses of lithium can cause a number of adverse side-effects. Additionally, high lithium blood levels can be toxic: however, this can be avoided through careful monitoring by a physician [ 10 ].
The much smaller amounts of active lithium contained in supplements are believed to make negative side-effects less likely. Based on anecdotal evidence, some people taking lithium orotate experience headaches, nausea, and diarrhea.
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