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Local Anesthesia for Surgical Procedures. Medications for Knee Pain. The 9 Best Arthritis Creams of Everything to Know About Nonsurgical Rhinoplasty. Why Is Shingles So Concerning? They work by blocking nerves from sending pain signals to the brain.
The result is temporary numbness of the area on which they are applied a "local" anesthetic. Because of their numbing effect, topical anesthetics are effective in treating pain such as sunburns, cuts or scrapes, insect bites, cold sores, rashes, hemorrhoids, injuries of the eye, or a sore throat.
However, they should not be used to relieve teething discomfort in children. However, misuse, overuse, or overdose can lead to a number of serious health problems and even death. Ingestion of lidocaine can cause numbness of the mouth and throat, which can lead to trouble swallowing and even choking. If a substantial amount is ingested, enough can be absorbed into the bloodstream to affect vital organs, primarily the brain and heart.
Symptoms can range from mild drowsiness and headache to confusion, seizures, coma, and cardiac arrest. It is important to note that these effects can result from excessive topical use or misuse of lidocaine as well. For example, covering a large area of the body with lidocaine or leaving it on the skin for a long time can lead to absorption of the drug into the bloodstream.
Wrapping the treated area also increases absorption. Another serious effect of lidocaine is a condition known as methemoglobinemia. Lidocaine can impair the ability of iron in red blood cells to carry oxygen to the tissues. Patients with congenital or idiopathic methemoglobinemia or patients taking medications associated with increased risk of methemoglobinemia including sulfonamides, acetaminophen, acetanilid, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, paraaminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, quinine will be excluded.
Patients with past or present neurologic disorders i. Contacts and Locations. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.
More Information. Publications automatically indexed to this study by ClinicalTrials. Drug Alcohol Depend. Epub May National Library of Medicine U. National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Cocaine Addiction. Drug: lidocaine following cue-induced craving Drug: lidocaine following neutral stimulus Drug: saline. Phase 2. Study Type :. Interventional Clinical Trial. Actual Enrollment :. Study Start Date :. Conclusion In summary, euphoria is a very rare side effect of systemic toxicity that can occur after lidocaine injection.
Acknowledgments We would like to thank Editage www. Funding Statement No funding was received for this report. Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure The authors declare that they have no competing interests for this work. References 1. McCaughey W.
Adverse effects of local anaesthetics. Drug Saf. Scott DB. Toxic effects of local anaesthetic agents on the central nervous system. Br J Anaesth. The plasma concentrations and systemic toxicity of lidocaine after maximal or supramaximal recommended doses of epidural administration.
Korean J Pain. Pharmacokinetics and pharmacodynamics of lignocaine: a review. World J Anesthesiol. The erector spinae plane block: a novel analgesic technique in thoracic neuropathic pain.
Reg Anesth Pain Med. The arterial supply of the cervical and thoracic spinal muscles and overlying skin: anatomical study with implications for surgical wound complications. Clin Anat. Comparison of injectate spread and nerve involvement between retrolaminar and erector spinae plane blocks in the thoracic region: a cadaveric study.
Systemic absorption of lidocaine from continuous erector spinae plane catheters after congenital cardiac surgery: a retrospective study.
J Cardiothorac Vasc Anesth. Zeidan A, Baraka A. Is euphoria a side-effect of lidocaine? Am J Psychiatry.
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